@article{10772, author = {Bazilevs Y. and M.-C Hsu and Yan Zhang and W. Wang and T. Kvamsdal and Susanne Hentschel and J. Isaksen}, title = {Computational Vascular {fl}uid-structure Interaction: Methodology and Application to Cerebral Aneurysms}, abstract = {A computational vascular fluid-structure interaction framework for the simulation of patient-specific cerebral aneurysm configurations is presented. A new approach for the computation of the blood vessel tissue prestress is also described. Simulations of four patient-specific models are carried out, and quantities of hemodynamic interest such as wall shear stress and wall tension are studied to examine the relevance of fluid-structure interaction modeling when compared to the rigid arterial wall assumption. We demonstrate that flexible wall modeling plays an important role in accurate prediction of patient-specific hemodynamics. Discussion of the clinical relevance of our methods and results is provided.}, year = {2010}, journal = {Biomechanics and Modeling in Mechanobiology}, volume = {9}, number = {4}, pages = {481-498}, doi = {10.1007/s10237-010-0189-7}, }