@inproceedings{13380, author = {Henrik Finsberg and Gabriel Balaban and Joakim Sundnes and Marie Rognes and Hans Odland and Stian Ross and Samuel Wall}, title = {Personalization of a Cardiac Compuational Model using Clinical Measurements}, abstract = {Important features in cardiac mechanics that cannot easily be measured in the clinic, can be computed using a computational model that is calibrated to behave in the same way as a patient{\textquoteright}s heart. To construct such a model, clinical measurements such as strain, volume and cavity pressure are used to personalize the mechanics of a cardiac computational model. The problem is formulated as a PDE-constrained optimization problem where the minimization functional represents the misfit between the measured and simulated data. The target parameters are material parameters and a spatially varying contraction parameter. The minimization is carried out using a gradient based optimization algorithm and an automatically derived adjoint equation. The method has been tested on synthetic data, and is able to reproduce a prescribed contraction pattern on the left ventricle.}, year = {2015}, journal = {28th Nordic Seminar on Computational Mechanics}, volume = {28}, pages = {47-50}, month = {10/2015}, publisher = {Proceedings of NSCM-28}, address = {Tallin, Estonia}, }