@inproceedings{14032, keywords = {parameter estimation, Cardiac Mechanics, Adjoint Method, PDE-constrained optimization}, author = {Henrik Finsberg and Gabriel Balaban and Marie Rognes and Joakim Sundnes and Samuel Wall}, title = {Optimization of a Spatially Varying Cardiac Contraction parameter using the Adjoint Method}, abstract = {A cardiac computational model is constrained using clinical measurements such as pressure, volume and regional strain. The problem is formulated as a PDE-constrained optimisation problem where the objective functional represents the misfit between measured and simulated data. The control parameter for the active phase is a spatially varying contraction parameter defined at every vertex in the mesh. This makes gradient calculations using the adjoint approach computationally advantageous over standard finite difference approximations.}, year = {2016}, journal = {FEniCS{\textquoteright}16}, }