@article{16017, keywords = {CA2, CA3, consolidation, hippocampus, sequence prioritization}, author = {Tristan St{\"o}ber and Andrew Lehr and Torkel Hafting and Arvind Kumar and Marianne Fyhn}, title = {Selective neuromodulation and mutual inhibition within the CA3-CA2 system can prioritize sequences for replay}, abstract = {To make optimal use of previous experiences, important neural activity sequences must be prioritized during hippocampal replay. Integrating insights about the interplay between CA3 and CA2, we propose a conceptual framework that allows the two regions to control which sequences are reactivated. We suggest that neuromodulatory-gated plasticity and mutual inhibition enable discrete assembly sequences in both regions to support each other while suppressing competing sequences. This perspective provides a coherent interpretation for a variety of seemingly disconnected functional properties of CA2 and paves the way for a more general understanding of CA2.}, year = {2020}, journal = {Hippocampus}, volume = {30}, pages = {1228-1238}, publisher = {John Wiley \& Sons}, doi = {DOI: 10.1002/hipo.23256}, }