@inbook{16571,
  keywords = {conduction velocity, ion channels, EMI model},
  author = {Kristian Hustad and Ena Ivanovic and Adrian Recha and Abinaya Sakthivel},
  title = {Conduction Velocity in Cardiac Tissue as Function of Ion Channel Conductance and Distribution},
  abstract = {Ion channels on the membrane of cardiomyocytes regulate the propagation of action potentials from cell to cell and hence are essential for the proper function of the heart. Through computer simulations with the classical monodomain model for cardiac tissue and the more recent extracellular-membrane-intracellular (EMI) model where individual cells are explicitly represented, we investigated how conduction velocity (CV) in cardiac tissue depends on the strength of various ion currents as well as on the spatial distribution of the ion channels. Our simulations show a sharp decrease in CV when reducing the strength of the sodium (Na+) currents, whereas independent reductions in the potassium (K1 and Kr) and L-type calcium currents have negligible effect on the CV. Furthermore, we find that an increase in number density of Na+ channels towards the cell ends increases the CV, whereas a higher number density of K1 channels slightly reduces the CV. These findings contribute to the understanding of ion channels (e.g. Na+ and K+ channels) in the propagation velocity of action potentials in the heart.},
  year = {2022},
  journal = {Computational Physiology - Simula Summer School 2021 - Student Reports},
  volume = {12},
  chapter = {4},
  pages = {41 - 50},
  month = {05/2022},
  publisher = {Springer International Publishing},
  address = {Cham},
  issn = {2512-1677},
  isbn = {978-3-031-05163-0},
  url = {https://link.springer.com/chapter/10.1007/978-3-031-05164-7_4},
  doi = {10.1007/978-3-031-05164-7_4},
  editor = {Kimberly McCabe},
}