@article{17158,
  author = {Vegard Vinje and Bastian Zapf and Geir Ringstad and Per Eide and Marie Rognes and Kent-Andre Mardal},
  title = {Human brain solute transport quantified by glymphatic MRI-informed biophysics during sleep and sleep deprivation},
  abstract = {Human brain homeostasis requires carefully regulated transport of nutrients and waste, but its governing mechanisms are hard to quantify. By combining multi-modal gMRI data over 48 hours with high-fidelity inverse computational modelling, we here identify several potential transport mechanisms that best explain the clinical observations. Our findings support the combined roles of local, vascular and glymphatic-type clearance pathways within human brain tissue with tissue flow velocities on the order of $\mu$m/min, local clearance rates at the order of 10**(-3)/min, and enhanced diffusion by a factor 3.5, in sleeping and sleep-deprived subjects. Reduced advection fully explains reduced tracer clearance after sleep-deprivation, supporting the role of sleep and sleep deprivation on human brain clearance.},
  year = {2023},
  journal = {Fluids and Barriers of the Central Nervous System},
  volume = {20},
  number = {62},
  month = {08/2023},
  publisher = {Springer Nature},
  doi = {https://doi.org/10.1186/s12987-023-00459-8},
}